Author/Editor		Ma, Weihong; Compan, Vincent; Zheng, Wenxuan; Martin, Elizabeth; North, Alan R.; Verkhratsky, Alexei; Surprenant, Annmarie
Title		Pannexin 1 forms an anion-selective channel
Type		članek
Vol. and No.		Letnik 463, št. 4
Publication year		2012
Volume		str. 585-592
ISSN		0031-6768 - Pflugers Archiv : European journal of physiology
Language		eng
Abstract		Pannexin 1 (Panx1) is expressed in various mammalian tissues including the brain and immune cells. Here, we present evidence that Panx1 when expressed in mammalian cells, forms anion-selective channels, with a rank order of permeabilities: NO (3) (-)>%I(-)%>%Br (-)>%Cl (-) >%F (-)>>%aspartate (-)%%glutamate (-)%%gluconate(-). Single-channel Panx1-mediated currents have a unitary conductance around 68 pS. Our results show that Panx1 assembles into a membrane anion channel with a relatively low single-channel conductance.
Keywords		Pannexin 1 HEK293 anion channel single channel