Author/Editor		Lešničar, H; Šmid, L; Zakotnik, B; Fajdiga, I
Title		Early glottic cancer: factors influencing treatment outcome
Type		članek
Source		In: Smee R, Bridger GP, editors. Laryngeal cancer. Proceedings of the 2nd world congress in laryngeal cancer; 1994 Feb 20-24; Sydney. Amsterdam: Elsevier,
Publication year		1994
Volume		str. 331-5
Language		eng
Abstract		In a retrospective analysis, 267 patients with previously untreated squamous-cell glottic carcinomas of types stage I (187) or stage II (80) were studied. Primary treatment involved radiotherapy for 219 patients (T1/159 and T2/60), surgery for 44 patients, (T1/28 and T2/16) or both in four T2 patients treated with radiotherapy in comparison to those who received operations was 82 and 92 percent for T1, and 69 percent for T2 respectively. In the radiotherapy group 26/159 T1 patients (16 percent) and 32/60 T2 patients (53 percent) had local recurrences which were salvaged by surgery in 70 percent of cases. Out of seven patients in surgery group 2 (16 percent), where salvaged with surgery. The influence of the type of tumor growth on the recurrence rate in the radiotherapy group was found statistically significant for infiltrative growth (15/23) in comparison to exofitic type (22/122), especially for T2 tumors (p=0.01). In patients whose treatment exceeded a duration of radiotherapy over the median 47 days, a greater proportion of relapses were observed. Although histologic grades, as well as a combination of impaired mobility of the vocal chords involving the supra- or subglottis, worsen prognosis after radiotherapy this was not to be found significant in our univariate analysis. Due to old age and a high incidence of new primary malignomas in our patients, overall survival was strongly affected; however, disease-specific survival was 93 percent in T1 and 81 percent in T2 tumors. Side effects of treatment were tolerable and no major toxicity was found. In the T2 group the fact that after radiotherapy and salvage surgery preservation of voice was achieved in 67 percent of patients, this in our opinion justifies the use of primary radiotherapy now as well in the future. Prospective randomized studies are needed, using innovative raidotherapy regimens.
Descriptors		LARYNGEAL NEOPLASMS GLOTTIS TREATMENT OUTCOME NEOPLASM STAGING CARCINOMA, SQUAMOUS CELL SURVIVAL RATE PHONATION