| Author/Editor | Meden-Vrtovec, H; Tomaževič, T | |
| Title | Preventing severe ovarian hyperstimulation syndrome in an in vitro fertilization - embryo transfer program: use of follicular aspiration after human chorionic gonadotropin administration | |
| Type | članek | |
| Source | J Reprod Med | |
| Vol. and No. | Letnik 40, št. 1 | |
| Publication year | 1995 | |
| Volume | str. 37-40 | |
| Language | eng | |
| Abstract | In 3,792 human menopausal gonadotropin (hMG) and human chorionic gonadotropin hCG)-stimulated menstrual cycles, severe ovarian hyperstimulation syndrome (SOHSS) developed in 10 patients (0.25 percent), while in 627 hMG-, hCG- and gonadotropin releasing hormone analog (GnRH-a)-stimulated cycles, 6 patients (0.95 percent) developed SOHSS. In cases of threatening SOHSS in the follicular phase (excessive estradiol values, multiple follicles), a preventive method was applied: follicular aspiration 12 hours after hCG administration and regular oocyte retrieval 36 hours after hCG (17 patients). The method of post-hCG aspiration in one ovary was effective, leading to the withdrawal of all signs of SOHSS within six days after the second aspiration. In hMG-stimulated, pretreated patients there were four deliveries of seven healthy infants (two singleton, one twin and one triplet), while one pregnancy in seven GnRH-a-stimulated and pretreated patients ended in a spontaneous abortion. Post-hCG aspiration is a quick, simple and effective method that prevents the development of SOHSS and permits pregnancy in the treated cycle. Although the pregnancy rate in patients who developed SOHSS was higher (100 percent per embryo trasfer), one should also consider the higher spontaneous abortion rate (33.3 percent for the hMG- and 50 percent for the GnRH-a/hMG-treated groups) and the fact that SOHSS is a lifethreatening condition, demending expensive, intensive care. Acconding to our experience, post-hCG follicular aspiration is the treatment of choice in patients with signs of SOHSS. | |
| Descriptors | OVARIAN HYPERSTIMULATION SYNDROME GONADOTROPINS, CHORIONIC FERTILIZATION IN VITRO EMBRYO TRANSFER MENOTROPINS PREGNANCY SUCTION GRAAFIAN FOLLICLE |