Author/Editor		Svetic, Branka; Prodan Žitnik, Irena; Gantar, Helena; Avberšek-Lužnik, Ivica
Title		Klinična uporabnost laboratorijskih testov pri preiskovancih z diagnozo odvisnosti od alkohola
Type		članek
Source		In: Zdravstvene stroke in njihov odziv na zdravstvene potrebe družbe: na dokazih podprto in usklajeno delovanje : zbornik predavanj z recenzijo, Bled, 11.-12. junij 2015 : = Proceedings of lectures with peer review, 11th - 12th June 2015, Bled Jesenice : Fakulteta za zdravstvo
Publication year		2015
Volume		str. 324-330
Language		slv
Abstract		Teoretična izhodišča: Odvisnost od alkohola je v naši družbi razširjen pojav, ki je povezan z negativnimi socialnimi in zdravstvenimi posledicami. Pomembno je zgodnje odkrivanje posameznikov, ki so zaradi različnih dejavnikov nagnjeni k prekomernemu uživanju alkohola. Specifične laboratorijske preiskave predstavljajo uporabno diagnostično orodje, zato želimo predstaviti že uveljavljene označevalce alkoholizma (MCV, AST, ALT, GGT, CDT) in novejši laboratorijski test - ELF test, ki se v tujini že uporablja za odkrivanje in ocenjevanje stopnje jetrne fibroze. Preiskovanci in metode: V prospektivno raziskavo smo vključili 90 preiskovancev, ki so bili na obdobnem zdravstvenem pregledu v ambulanti Medicine dela, prometa in športa (MDPŠ) in 43 bolnikov s potrjeno diagnozo odvisnosti od alkohola (DOA). V vzorcih krvi smo izmerili: povprečni volumen eritrocitov (MCV), aktivnost encimov (AST, ALT, GGT) in izvedli meritve parametrov ELF testa. Za analizo primerjav med skupinama preiskovancev smo uporabili statistični program SPSS 21.0 za Windows okolje (SPSS, Inc. Chicago, USA). Rezultati : Rezultati meritev so pokazali, da so aktivnosti encimov (AST, GGT) in MCV značilno višje pri bolnikih skupine DOA v primerjavi s preiskovanci MDPŠ (p<0,002). Primerjave med označevalci alkoholizma in ELF testom so pokazale statistično značilne razlike za vse preiskovane parametre med skupinama MDPŠ in DOA (p<0,05). Razprava in zaključek: Rezultati naše raziskave so primerljivi z izsledki podobnih raziskav. ELF test je v tujini diagnostično uporaben za odkrivanje in spremljanje razvojnih stopenj jetrne fibroze. Menimo, da bi bilo potrebno začeti z uporabo ELF testa tudi v Sloveniji, še posebej pri bolnikih z diagnozo odvisnosti od alkohola in tudi pri tistih, ki se vključujejo v proces zdavljenja odvisnosti od alkohola. KljučneBackground: Excessive use of alcohol is highly prevalent in the modern society and it is associated with negative social and health consequences. Early detection of individuals with alcohol dependence is very important. Biochemical markers that indicate the pathological effects of alcohol and its metabolites are useful in diagnosing, managing and monitoring of alcoholism. The aim of our study was to present the associations between well-established biochemical markers of alcoholism (AST, ALT, GGT, MCV) and the more recent ELF (Enhanced Liver Fibrosis) test for detecting the presence and assessing the degree of liver fibrosis. Participants and methods: In the prospective study 133 individuals were included. 90 participants were recruited from the occupational health (OH) clinic and 43 individuals with chronic alcohol dependence (AD). The following tests were performed in all participants using routine methods: AST, ALT, GGT, MCV and ELF test. Statistical package SPSS 21.0 for Windows (SPSS, Inc. Chicago, USA) was used for statistical analysis. Results: The biochemical tests showed that the enzyme activities (AST, GGT) and MCV were significantly higher in the individuals with AD compared to the OH participants (p<0,002). Comparison between the measured concentrations of biomarkers and ELF test showed statistically significant differences in all biochemical parameters in the OH and AD group (p<0,05). Discussion and conclusions: The results of our study are comparable with similar studies. On the basis of these results we conclude that the ELF test is useful for detection and managing of liver fibrosis. ELF test should be studied further and its use evaluated in the patients diagnosed with alcohol dependency when starting treatment and during follow-up in Slovenia, too. It seems to be promising also for the use in primary health care for early detection of individuals at risk to develop chronic liver disease.
Keywords		alkoholiki laboratorijske preiskave