Author/Editor		Rubtsov, AM; Schara, M; Šentjurc, M; Boldyrev, AA
Title		Hydroxyl radical-scavenging activity of carnosine: a spin trapping study
Type		članek
Source		Acta Pharm Jugosl
Vol. and No.		Letnik 41
Publication year		1991
Volume		str. 401-7
Language		eng
Abstract		Carnosine (beta-alanyl-L-histidine) was described as an efective protector of biological membranes against lipid peroxidation, probably because of its scavenging properties, found recently in some biological systems. To understand better the protective function of this, natural histidine-containing dipeptide, its interaction with hydroxyl radical has been studied with the use of spin traps, alfa-phenyl-N-tert-butyl nitrone (PBN) and 5,5-dimethylppyrroline-1-oxide (DMPO). Carnosine decreases significantly the amount of PBN/.OH and DMPO/.OH radical adducts formed in aquecous solution of H2O2 after UV-irradiation or during the Fenton reaction induced by FeCL2. In addition, carnosine decreases drastically the life-time of DMPO/.OH in H2O2 solution. It is concluded that carnosine is an efficient scavenger of hydroxyl radical and interacts also with the radical adducts of the spin traps used.
Descriptors		CARNOSINE HYDROXYL RADICAL FREE RADICAL SCAVENGERS ULTRAVIOLET RAYS