Author/Editor | Lončar, Goran; Tscholl, Verena; Tahirović, Elvis; Šekularac, Nikola; Marx, Almuth; Obradovic, Danilo; Veskovic, Jovan; Lainščak, Mitja; Von Haehling, Stephan; Edelmann, Frank; Arandjelovic, Aleksandra; Apostolović, Svetlana; Stanojevic, Dragana; Pieske, Burkert; Trippel, Tobias D.; Düngen, Hans-Dirk | |
Title | Should procalcitonin be measured routinely in acute decompensated heart failure? | |
Type | članek | |
Vol. and No. | Letnik 9, št. 7 | |
Publication year | 2015 | |
Volume | str. 651-659 | |
ISSN | 1752-0363 - Biomarkers in medicine | |
Language | eng | |
Abstract | Aim: to elucidate the prognostic role of procalcitonin (PCT) in patients with acute decompensated heart failure (ADHF) without clinical signs of infection at admission. Materials & Methods: Serial measurement of PCT and NT-proBNP were performed in 168 patients, aged 68 +/-10 years with ADHF followed by 3-month outcome evaluation. Results: Cox regression analysis demonstrated significant predictive value of baseline PCT for all-cause death/hospitalization (area under the curve: 0.67; p = 0.013) at 90th day. The patients with persistently elevated PCT or with an increase during the first 72 h of hospitalization had the worst prognosis (p = 0.0002). Conclusion: Baseline and serial in-hospital measurements of PCT have significant prognostic properties for 3-month all-cause mortality/hospitalization in patients with ADHF without clinical signs of infection at admission. | |
Descriptors | Heart failure Outcome assessment Calcitonin Srce, odpoved Izid bolezni, napoved Kalcitonin |