Author/Editor     Lončar, Goran; Tscholl, Verena; Tahirović, Elvis; Šekularac, Nikola; Marx, Almuth; Obradovic, Danilo; Veskovic, Jovan; Lainščak, Mitja; Von Haehling, Stephan; Edelmann, Frank; Arandjelovic, Aleksandra; Apostolović, Svetlana; Stanojevic, Dragana; Pieske, Burkert; Trippel, Tobias D.; Düngen, Hans-Dirk
Title     Should procalcitonin be measured routinely in acute decompensated heart failure?
Type     članek
Vol. and No.     Letnik 9, št. 7
Publication year     2015
Volume     str. 651-659
ISSN     1752-0363 - Biomarkers in medicine
Language     eng
Abstract     Aim: to elucidate the prognostic role of procalcitonin (PCT) in patients with acute decompensated heart failure (ADHF) without clinical signs of infection at admission. Materials & Methods: Serial measurement of PCT and NT-proBNP were performed in 168 patients, aged 68 +/-10 years with ADHF followed by 3-month outcome evaluation. Results: Cox regression analysis demonstrated significant predictive value of baseline PCT for all-cause death/hospitalization (area under the curve: 0.67; p = 0.013) at 90th day. The patients with persistently elevated PCT or with an increase during the first 72 h of hospitalization had the worst prognosis (p = 0.0002). Conclusion: Baseline and serial in-hospital measurements of PCT have significant prognostic properties for 3-month all-cause mortality/hospitalization in patients with ADHF without clinical signs of infection at admission.
Descriptors     Heart failure
Outcome assessment
Calcitonin
Srce, odpoved
Izid bolezni, napoved
Kalcitonin