Author/Editor		Goričar, Katja; Kovač, Viljem; Franko, Alenka; Dodič-Fikfak, Metoda; Dolžan, Vita
Title		Serum survivin levels and outcome of chemotherapy in patients with malignant mesothelioma
Type		članek
Vol. and No.		, št. Vol. 2015
Publication year		2015
Volume		str. 1-8
ISSN		0278-0240 - Disease markers
Language		eng
Abstract		Background. Survivin is an inhibitor of apoptosis protein involved in the regulation of cell proliferation that could be used as a marker for cancer diagnosis or prognosis. Our aimwas to evaluatewhether serumsurvivin levels influence the outcome of cisplatinbased chemotherapy in patients with malignant mesothelioma (MM). Methods. Serum survivin levels were determined using human survivin enzyme-linked immunosorbent assay in 78MMpatients before chemotherapy, after chemotherapy, and at disease progression. The influence on tumor response and survival was evaluated using nonparametric tests and Cox regression. Results. A median serum survivin level at diagnosis was 4.1 (0%217.5) pg/mL. Patients with a progressive disease had significantly higher survivin levels before chemotherapy (p = 0.041). A median serum survivin level after chemotherapy was 73.1 (0%346.2) pg/mL. If survivin levels increased after chemotherapy, patients had, conversely, better response (p = 0.001, OR = 5.40, 95% CI = 1.98%14.72). Unexpectedly, patients with increased survivin levels after chemotherapy also had longer progression-free (p < 0.001, HR = 0.33, 95% CI = 0.20%0.57) and overall survival (p = 0.001, HR = 0.29, 95% CI = 0.14%0.58). Conclusions. These results suggest that serum survivin levels before and during chemotherapy could serve as a biomarker predicting MM treatment response.
Keywords		malignant mesothelioma chemotherapy serum survivin levels maligni mezoteliom kemoterapija serumska raven survivina