Author/Editor		Brinovec, V
Title		Naše izkušnje s cepljenjem zdravstvenih delavcev proti hepatitisu B z rekombinantnim cepivom in upravičenost spodbujevalnih odmerkov
Translated title		Our experience in vaccination of medical personnel with the recombinant hepatitis B vaccine and justification of booster doses
Type		članek
Source		Zdrav Vestn
Vol. and No.		Letnik 64, št. 5
Publication year		1995
Volume		str. 253-6
Language		slo
Abstract		Background. The hepatitis B virus infection (HBV) is by far more frequent among medical personnel than in the general population. According to the available data the prevalence of hepatitis B markers is 12.7 percent among medical personnel of the Medical Centre Ljubljana and the Public Health Service of Ljubljana (1). Therefore the decision was made to start an active immunization programme with a recombinant hepatitis B vaccine. According to the Slovenian regulations vaccination against hepatitis B is obligatory for all risk groups. For the medical personnel in Slovenia obligatory vaccination against hepatitis B was introduced in December, 1987. Results. According to the results of the present study which was started in 1989, vaccination conferred protection against hepatitis B in 91.5 percent of cases. Out of the total number of 558 initially vaccinated subjects, 48 (8.5 percent) were classified as nonresponders or hyporesponders after the final (third) dose. Conclusions. By additional booster doses after the final (third) dose the number of real non-responders was reduced to 4 (0.7 percent) out of 558 subjects enrolled.
Summary		Izhodišča. Okužba z virusom hepatitisa B (HBV) je pri zdravstvenih delavcih veliko pogostnejša kot pri splošnem prebivalstvu. Po dosegljivih podatkih znaša razširjenost označevalcev hepatitisa B 12,7 odstotka pri zdravstvenih delavcih Kliničnega centra Ljubljana in Zdravstvenega doma Ljubljana (1). Na teh podatkih je temeljila odločitev za aktivni program imunizacije z rekombinantnim cepivom proti hepatitisu B. Slovenski zakon določa, da je cepljenje proti hepatitisu B obvezno za vse skupine s tveganjem. V Sloveniji je postalo cepljenje proti hepatitisu B za zdravstvene delavce obvezno decembra leta 1987. Rezultati. Rezultati pričujoče raziskave, ki poteka od leta 1989, kažejo, da je uspelo s cepljenjem proti hepatitisu B pred boleznijo zaščititi 91,5 odstotka cepljenih oseb. Od skupno 558 v raziskavo zajetih oseb jih je bilo po prvem cepljenju 48 (8,5 odstotka) neodzivnikov ali slabih odzivnikov po zadnjem (tretjem) odmerku. Zaključki. Z dodatnimi, spodbujevalnimi odmerki po zadnjem (tretjem) odmerku cepiva se je število resničnih neodzivnikov zmanjšalo na 4 (0,7 odstotka) od v raziskavo vključenih 558 oseb.
Descriptors		HEPATITIS B HEPATITIS B VACCINES HEALTH MANPOWER VACCINES, SYNTHETIC HEPATITIS B ANTIBODIES