Author/Editor		Hafner, Matjaž; Ferlan-Marolt, Vera
Title		Hepatocelularni karcinom (HCK)
Type		monografija
Place		Ljubljana
Publisher		[M. Hafner]
Publication year		1996
Volume		str. 45 f.
Language		eng
Abstract		The autopsy reports, clinical records and liver tissue specimens of patients with hepatocellular carcinoma (HCC) who underwent post- mortem examination at the Institute of Pathology in Ljubljana in the period 1985 - 1994 were retrospectively reviewed to assess the epidemiological, clinical and pathomorphological characteristics of HCC in Slovenia. Fifty cases of HCC weredocumented in a total of 10.70l autopsy reports dating from the period covered by the survey. In the study population, HCC developed mostly in the 6th decade of life (32%) and was 3.5 times more common in men than in women. The great majority of patients (84%) had associated liver cirrhosis, the causeof which was mostly unknown during life. In patients with known etiology,the predominant cause was alcohol. Chronic hepatitis B infection was less common in our patients with HCC (8%) than in other comparable populationsin southern and western Europe. The detection of chronic hepatitisC infection was not yet possible during the study period, and so its relation to HCC could not be evaluated. Only a smll proportion of HCC cases (28%) were diagnosed on clinical grounds before death. According to the macroscopic growth pattern, HCC occured most often in the form of a multinodular tumour (47%). Solitary small lesions measuring less than 3 cm in diameter were extremely rare (4%). Diffuse and massive tumours accounted for 16% of the cases each. Comparison of the macroscopic growth pattern with the tumour size, histological growth pattern and histological grade did not revealany significant relationships aside from a significantly greater averagediameter manifested by massive tumours as compared to other forms. According to histological grading, most of the carcinomas were moderately differentiated (73%), 21 % were well differentiated and only 6% were poorly differentiated. (Abstract truncated at 2000 characters)
Descriptors		Carcinoma, hepatocellular Carcinoma, hepatocellular Carcinoma, hepatocellular Karcinom hepatocelularni Karcinom hepatocelularni Karcinom hepatocelularni Etiology Epidemiology Pathology Etiologija Epidemiologija Patologija