Author/Editor		Vera-Badillo, Francisco Emilio; Chang, Martin; Kuruzar, Gordana; Ocaña, Alberto; Templeton, Arnoud J.; Šeruga, Boštjan; Goldstein, Robyn; Bedard, Philippe L.; Tannock, Ian; Amir, Eitan
Title		Association between androgen receptor expression, Ki-67 and the 21-gene recurrence score in non-metastatic, lymph node-negative, estrogen receptor-positive and HER2-negative breast cancer
Type		članek
Vol. and No.		Letnik 68, št. 10
Publication year		2015
Volume		str. 839-843
ISSN		0021-9746 - Journal of clinical pathology
Language		eng
Abstract		The mechanisms underlying the favourable prognosis of androgen receptor (AR) expression in breast cancer are unknown. METHODS: The associations between the 21-gene recurrence score (RS), AR, grade, mitotic score, Ki-67 and estrogen receptor (ER) and progesterone receptor (PgR) expression were explored in sequential women with lymph node-negative, ER-positive and HER2-negative breast cancer. Statistical significance of this exploratory study was defined as p<0.10. RESULTS: Analysis comprised 70 women. Most tumours had high AR expression (97% had scores >3). Median RS was 15 (range 1-53). AR expression showed a minimally significant positive correlation with ER (R=0.37), but no correlation with Ki-67 (R=-0.18). In univariable analysis, AR (p=0.01), ER (p<0.001) and PgR (p<0.001) had significant negative associations with RS. Ki-67 (p=0.16), grade (p=0.40) and mitotic score (p=0.23) showed no association with RS. Multivariable analysis showed similar associations. CONCLUSIONS: AR is associated with lower RS, but not with Ki-67.
Keywords		rak dojke hormonsko odvisni rak androgenski receptorji breast cancer androgen receptor Ki-67