| Author/Editor | Ramlau, Rodryg; Čufer, Tanja; Kern, Izidor | |
| Title | Epidermal growth factor receptor mutation-positive non-small-cell lung cancer in the real-world setting in Central Europe | |
| Type | članek | |
| Vol. and No. | Letnik 10, št. 9 | |
| Publication year | 2015 | |
| Volume | str. 1370-1374 | |
| ISSN | 1556-0864 - Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer | |
| Language | eng | |
| Abstract | The ImplementatioN of perSonalized medicine In NSCLC in Central Europe: EGFR testing, Histopathology, and clinical feaTures (INSIGHT) observational study assessed both implementation of epidermal growth factor receptor (EGFR) mutation testing and treatment of patients with advanced EGFR mutation-positive non-small-cell lung cancer (NSCLC) in a real-world setting in Central Europe. A total of 1785 patients from 14 cancer centers of six Central European countries were enrolled. EGFR mutations were detected in tumors of 13.8% of the patients. More than 70% of patients with advanced EGFR mutation-positive NSCLC received EGFR tyrosine kinase inhibitors as first-line therapy. The INSIGHT study demonstrated the establishment of EGFR mutation testing, a mutation rate consistent with other Caucasian patients populations, and adherence to current guidelines regarding treatment of patients with EGFR mutation-positive tumors in Central Europe. | |
| Keywords | tarčna terapija INSIGHT EGFR mutacije molekularna analiza targeted therapy EGFR mutations molecular analysis |