Author/Editor		Jeraj, Robert; Cao, Y.; Haken, T.; Hann, C.; Marks, L.
Title		Imaging for Assessment of Radiation-Induced Normal Tissue Effects
Type		članek
Vol. and No.		Letnik Iss. 3, št. Vol. 76
Publication year		2010
Volume		str. S140-S144
ISSN		0360-3016 - International journal of radiation oncology, biology, physics
Language		eng
Abstract		Imaging can provide quantitative assessment of radiation-induced normal tissueeffects. Identifying an early sign of normal tissue damage with imaging would have the potential to predict organ dysfunction, thereby allowing reoptimization of treatment strategies based on individual patientsć risks andbenefits. Early detection with noninvasive imaging may enable interventionsto mitigate therapy-associated injury before its clinical manifestation. Furthermore, successive imaging may provide an objective assessment of the impact of such mitigation therapies. However, many problems make application of imaging to normal tissue assessment challenging, and further work is required to establish imaging biomarkers as surrogate endpoints of clinical outcome. The performance of clinical trials in which normal tissue injury is a clearly defined endpoint would greatly aid in realization of these goals.
Keywords		radioterapija