Author/Editor		Sezer, Engin; Luzar, Boštjan; Calonje, Eduardo
Title		Secondary syphilis with an interstitial granuloma annulare-like histopathologic pattern
Type		članek
Vol. and No.		Letnik 38, št. 5
Publication year		2011
Volume		str. 439-442
ISSN		0303-6987 - Journal of cutaneous pathology
Language		eng
Abstract		A granulomatous tissue response may be observed in untreated, long-standing lesions of secondary syphilis. In addition to poorly defined granulomatous inflammation, leprosy-like sarcoidal and palisaded granulomatous inflammation has been documented in literature reports of lues. Herein, we report a 47-year-old man who presented with a 3-month history of a generalized non-pruritic macular and papular rash located on the trunk and extremities. Histopathologically, there was an interstitial arrangement of histiocytes with occasional multinucleated giant cells positioned among collagen bundles without associated necrosis, thereby closely mimicking interstitial granuloma annulare. A clue to the diagnosis was the presence of admixed plasma cells. To the best of our knowledge, this is the first reported case of secondary syphilis showing an interstitial granulomatous pattern mimicking interstitial granuloma annulare.
Keywords		syphilis immunohistochemistry granulomatous tissue sifilis imunohistokemija granulomatozno tkivo