Author/Editor | Suchak, Ravi; Luzar, Boštjan; Bacchi, Carlos E.; Maguire, Brigid; Calonje, Eduardo | |
Title | Cutaneous neuroblastoma-like schwannoma | |
Type | članek | |
Vol. and No. | Letnik 37, št. 9 | |
Publication year | 2010 | |
Volume | str. 997-1001 | |
ISSN | 0303-6987 - Journal of cutaneous pathology | |
Language | eng | |
Abstract | Cutaneous schwannomas in their classical form are readily identified histologically. A number of variants, including ancient, cellular, epithelioid, plexiform, microcystic and neuroblastoma-like, may cause diagnostic difficulty and rarely be confused with malignancy. Neuroblastoma-like schwannoma was first described by Goldblum et al. in 1994, and very few cases have since been reported. It is a benign sporadic neoplasm with no reported association with neurofibromatosis, and is characterized histologically by small round lesional cells surrounding collagenous cores forming rosette-like structures. The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma. We describe two further cases of this rare entity and review the literature on the subject. Our first case additionally has a plexiform multinodular pattern, a feature described in only one previous report. | |
Keywords | neuroblastoma schwannoma benign neoplasm neuroblastom švanom benigna neoplazma |