Author/Editor		Pajares, Marta; Jiménez-Moreno, Natalia; Dias, Irundika H. K.; Debelec, Bilge; Vucetic, Milica; Fladmark, Kari E.; Basaga, Huveyda; Ribarič, Samo; Milisav, Irina; Cuadrado, Antonio
Title		Redox control of protein degradation
Type		članek
Vol. and No.		, št. Vol. 6
Publication year		2015
Volume		str. 409-420
ISSN		2314-6141 - BioMed research international
Language		eng
Abstract		Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well as the impact of reactive oxygen species on the proteolytic systems that regulate cell response to an oxidant environment: the ubiquitin-proteasome system (UPS), autophagy and the unfolded protein response (UPR). In the presence of an oxidant environment, these systems are critical to ensure proteostasis and cell survival. An example of altered degradation of oxidized proteins in pathology is provided for neurodegenerative diseases. Future work will determine if protein oxidation is a valid target to combat proteinopathies.
Keywords		protein oxidation proteolysis autophagy oksidacija proteinov proteoliza avtofagija