Author/Editor		Mrhar, A; Karba, R; Irman-Florjanc, T; Primožič, S; Erjavec, F
Title		Modeling and computer simulation of histamine pharmacokinetics
Type		članek
Source		In: Troch I, Breitenecker F, editors. 1. Mathmod Vienna. Proceedings of the IMACS symposium on mathematical modelling; 1994 Feb 2-4; Vienna. Vienna: Technical university,
Publication year		1994
Volume		str. 340-3
Language		eng
Abstract		Histamine plays an important role in physiologic and many pathophysiologic conditions. One of the main products of histamine metabolism is tele-methylhistamine and the second important pathway of histamine biostransformation is oxidative deamination. On the basis of plasma concentrations, obtained after intravenous doses of histamine and methylhistamine to the rats in two separate groups of experiments, a four-compartment model was developed by the aid of anolog-hybrid simulation. The results showed that kinetics of tele-methylhistamine and histamine are comparable as well as kinetics of exogenous and endogenous tele-methylhistamine. It was also found out that demethylation of tele-methylhistamine and/or displacement of histamine from mast cells occurs only in the case of very high plasma levels of methylhistamine, whereas the rate of hystamine metabolic pathways other than methylation are increased after injection of histamine. The results confirmed that processes of histamine metabolism are adaptable.
Descriptors		HISTAMINE METHYLHISTAMINES RATS ANIMALS, LABORATORY INJECTIONS, INTRAVENOUS COMPUTER SIMULATION