Author/Editor		Cimperman, J; Maraspin, V; Lotrič, S; Picken, RN; Ružić-Sabljić, E; Avšič-Županc, T; Strle, F
Title		Concomitant infection with tick-borne encephalitis virus and Borrelia burgdorferi in patients with acute meningitis or meningoencephalitis
Type		članek
Source		In: Cevenini R, Sambri V, La Placa M, editors. Advances in Lyme borreliosis research. Proceedings of the 6th international conference on Lyme borreliosis; 1994 Jun 19-22; Bologna. Bologna: The University of Bologna,
Publication year		1994
Volume		str. 152-5
Language		eng
Abstract		In 1993 we treated 338 patients over the age of 15 years who presented with acute lymphocytic meningitis. In 89 patients (26.3 percent) tick-borne encephalitis (TBE) virus antibodies (IgM and IgG) were detected by ELISA. In 59 patients (17.5 percent) we demonstrated the borrelial etiology of disease by one or more of the following: presence of intrathecal antibodies (IFA, IgM and/or IgG without absorption), seroconversion to borrelial antigens, presence of erythema migrans (EM) with a positive titer for borrelial antibodies in the serum, and/or isolation of B. burgdorferi from skin of CSF. In 12 patients (8.1 percent) from both groups, concomitant infection with TBE virus and B. burgdorferi was demonstrated. Thus, all 12 patients had positive serological tests for the virus. In 6 of these patients, we also found positive serology for B. burgdorferi and an intrathecal formation of borrelial antibodies was confirmed. In addition, 3 patients had EM on admission, 2 had positive serological test for B. burgdorferi and the spirochete was isolated from the skin of 1 patient. A further 2 patients demonstrated seroconversion to B. burgdorferi and spirochetes were isolated from the CSF of one these patients.
Descriptors		ENCEPHALITIS, TICK-BORNE LYME DISEASE ENCEPHALITIS VIRUSES, TICK-BORNE BORRELIA BURGDORFERI