Author/Editor		Bossi, Paolo; Saba, Nabil F.; Vermorken, Jan B.; Strojan, Primož; Pala, Laura; De Bree, Remco; Rodrigo, Juan Pablo; López, Fernando; Hanna, Ehab Y.; Haigentz, Missak; Takes, Robert P.; Slootweg, Pieter Johannes; Silver, Carl E.; Silver, Carl E.; Rinaldo, Alessandra; Ferlito, Alfio
Title		The role of systemic therapy in the management of sinonasal cancer
Type		članek
Vol. and No.		Letnik 41, št. 10
Publication year		2015
Volume		str. 836-843
ISSN		0305-7372 - Cancer treatment reviews
Language		eng
Abstract		Due to the rarity and the variety of histological types of sinonasal cancers, there is a paucity of data regarding strategy for their optimal treatment. Generally, outcomes of advanced and higher grade tumors remain unsatisfactory, despite the employment of sophisticated surgical approaches, technical advances in radiation techniques and the use of heavy ion particles. In this context, we critically evaluated the role of systemic therapy as part of a multidisciplinary approach to locally advanced disease. RESULTS: Induction chemotherapy has shown encouraging activity and could have a role in the multimodal treatment of patients with advanced sinonasal tumors. For epithelial tumors, the most frequently employed chemotherapy is cisplatin, in combination with either 5-fluorouracil, taxane, ifosfamide, or vincristine. Only limited experiences with concurrent chemoradiation exist with sinonasal cancer. The role of systemic treatment for each histological type (intestinal-type adenocarcinoma, sinonasal undifferentiated carcinoma, sinonasal neuroendocrine carcinoma, olfactory neuroblastoma, sinonasal primary mucosal melanoma, sarcoma) is discussed. CONCLUSIONS: The treatment of SNC requires a multimodal approach. Employment of systemic therapy for locally advanced disease could result in better outcomes, and optimize the therapeutic armamentarium. Further studies are needed to precisely define the role of systemic therapy and identify the optimal sequencing for its administration in relation to local therapies.
Keywords		sinonazalen karcinom multimodalno zdravljenje kemoterapija tarčno zdravljenje sinonasal cancer multimodality treatment chemotherapy targeted therapy