Author/Editor		Gurianova, Veronika; Stroy, Dmytro; Ciccocioppo, Rachele; Gasparova, Iveta; Petrovič, Danijel; Soucek, Miroslav; Dosenko, Victor; Kruzliak, Peter
Title		Stress response factors as hub-regulators of microRNA biogenesis
Type		članek
Publication year		2015
ISSN		0263-6484 - Cell biochemistry and function
Language		eng
Abstract		MicroRNAs (miRNAs) are important regulators of heart function and then an intriguing therapeutic target for plenty of diseases. The problem raised is that many data in this area are contradictory, thus limiting the use of miRNA-based therapy. The goal of this review is to describe the hub-mechanisms regulating the biogenesis and function of miRNAs, which could help in clarifying some contradictions in the miRNA world. With this scope, we analyse an array of factors, including several known agents of stress response, mediators of epigenetic changes, regulators of alternative splicing, RNA editing, protein synthesis and folding and proteolytic systems. All these factors are important in cardiovascular function and most of them regulate miRNA biogenesis, but their influence on miRNAs was shown for non-cardiac cells or some specific cardiac pathologies. Finally, we consider that studying the stress response factors, which are upstream regulators ofmiRNA biogenesis, in the diseased heart could help in (1) explaining some contradictions concerning miRNAs in heart pathology, (2) making the role of miRNAs in pathogenesis of cardiovascular disease more clear, and therefore, (3) getting powerful targets for its molecular therapy.
Keywords		stress response factors regulators heart diseases odzivni faktorji stresa regulatorji bolezni srca