Author/Editor		Milisav, Irina; Šuput, Dušan; Ribarič, Samo
Title		Unfolded protein response and macroautophagy in Alzheimer's, Parkinson's and prion diseases
Type		članek
Vol. and No.		Letnik 20, št. 12
Publication year		2015
Volume		str. 22718-22756
ISSN		1420-3049 - Molecules (Basel, Switzerland)
Language		eng
Abstract		Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.
Keywords		Alzheimer's disease; autophagy Parkinson's disease Alzheimerjeva bolezen avtofagija Parkinsonova bolezen