Author/Editor | Glaser, M; Černelč, P | |
Title | Imunoglobulini pri zdravljenju bolnikov s kronično idiopatično trombocitopenično purpuro | |
Translated title | Immunoglobulin therapy in chronic idiopathic thrombocytopenic purpura | |
Type | članek | |
Source | Zdrav Vestn | |
Vol. and No. | Letnik 64, št. 7-8 | |
Publication year | 1995 | |
Volume | str. 427-8 | |
Language | slo | |
Abstract | Background. Adult chronic idiopathic thrombocytopenic purpura (ITP) is an autoimmune disease, which results from the formation of antibodies against the patient's own platelets. Patients with ITP and a platelet count of less than 20109/L, or bleeding, can be treated with glucocorticoids, immunoglobulins, splenectomy, cytostatics with immunosuppressive effect or androgens. Results. In the period 1990-1994, 5 adult patients (3 women, 2 men) with ITP and bleeding were treated with immunoglobulins before splenectomy. Treatment with glucocorticoids had been proven ineffective. After 5 days of intravenous immunoglobulin therapy (0.4 g/kg of body weight/day), the platelet count attained normal values in two patients, increased to 76109/L in one patient and remained low in two patients. After splenectomy, normal platelet counts were obtained in all 5 patients. p73 Conclusions. For patients with ITP and bleeding, immunoglobulin therapy is a successful method to achieve rapid elevation of the platelet count. It can be applied before splenectomy, some other operation or delivery. The effect of immunoglobulins usually disappears within a few days after the treatment has been stopped. | |
Summary | Izhodišča. Kronična idiopatična trombocitopenična purpura (ITP) odraslih je avtoimunska bolezen, ki je posledica nastanka protiteles proti lastnim trombocitom. Bolnike z ITP in trombocitopenijo z manj kot 20109/L ali krvavitvami lahko zdravimo z glukokortikoidi, imunoglobulini, splenektomijo, citostatiki z zaviralnim učinkom na imunski sistem in androgeni. Rezultati. V obdobju od leta 1990 do 1994 smo pred splenektomijo zdravili z imunoglobulini pet odraslih bolnikov (tri ženske, dva moška) z ITP in krvavitvami, pri katerih zdravljenje z glukokortikoidi ni bilo uspešno. Peti dan venskega zdravljenja z imunoglobulini (0,4 g/kg telesne teže/dan, 5 dni) se je pri dveh bolnikih število trombocitov zvečalo do normalnih vrednosti, pri enem je porastlo do 76109/L, pri dveh pa se ni zvečalo. Po splenektomiji se je pri vseh bolnikih povečalo število trombocitov do normalnih vrednosti. Zaključki. Zdravljenje z imunoglobulini je uspešen način zvečanja števila trombocitov že v nekaj dneh pri bolnikih z ITP in krvavitvami. Uporabljamo ga lahko pred splenektomijo in drugimi operacijami ter porodom. Učinek imunoglobulinov po navadi izzveni že v nekaj dneh po prenehanju dajanja. | |
Descriptors | PURPURA, THROMBOCYTOPENIC, IDIOPATHIC IMMUNOGLOBULINS |