Author/Editor		Horvat, Ana; Kravos, Nika Aleksandra; Goričar, Katja; Jensterle Sever, Mojca; Janež, Andrej; Dolžan, Vita
Title		SORCS1 polymorphism and insulin secretion in obese women with polycystic ovary syndrome
Type		članek
Publication year		2016
ISSN		0951-3590 - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Language		eng
Abstract		We investigated the influence of SORCS1 polymorphisms on insulin secretion in obese women with PCOS. Metabolic status was recorded in 50 clinically well characterized PCOS patients. Oral glucose tolerance test was performed and laboratory parameters of insulin resistance measured. All patients were genotyped for SORCS1 rs1358030, rs1416406 and rs11192966 polymorphisms. Statistical analysis was performed using the Mann-Whitney test. SORCS1 rs1416406 significantly influenced stimulated glucose plasma levels (p=0.006) and increased glucose stimulated insulin secretion (p=0.034). None of the polymorphisms influenced insulin resistance as measured by homeostatic model assessment. We report for the first time the relevance of SORCS1 polymorphisms for glycemic control and glucose stimulated insulin secretion in obese women with PCOS.
Keywords		insulin resistance SORCS1 polycystic ovary syndrome odpornost na insulin SORCS1 sindrom policističnih jajčnikov