Author/Editor		Maver, Tina; Maver, Uroš; Stana-Kleinschek, Karin; Mlinarič-Raščan, Irena; Smrke, Dragica
Title		Advanced therapies of skin injuries
Type		članek
Vol. and No.		Letnik Jg. 127, št. Supl. 5
Publication year		2015
Volume		str. S187-S198
ISSN		0043-5325 - Wiener klinische Wochenschrift
Language		eng
Abstract		The loss of tissue is still one of the most challenging problems in healthcare. Efficient laboratory expansion of skin tissue to reproduce the skins barrier function can make the difference between life and death for patients with extensive full-thickness burns, chronic wounds, or genetic disorders such as bullous conditions. This engineering has been initiated based on the acute need in the 1980s and today, tissue-engineered skin is the reality. The human skin equivalents are available not only as models for permeation and toxicity screening, but are frequently applied in vivo as clinical skin substitutes. This review aims to introduce the most important recent development in the extensive field of tissue engineering and to describe already approved, commercially available skin substitutes in clinical use.
Keywords		allograft autograft scaffold tissue-engineered skin tissue engineering