Author/Editor		López, Fernando; Strojan, Primož
Title		Update on primary head and neck mucosal melanoma
Type		članek
Vol. and No.		Letnik 38, št. 1
Publication year		2016
Volume		str. 147-155
ISSN		1097-0347 - Head & neck
Language		eng
Abstract		Primary mucosal melanomas (PMMs) of the head and neck are uncommon malignancies that arise mainly in the nasal cavity and paranasal sinuses, followed by the oral cavity. The mainstay of treatment is radical surgical resection followed by adjuvant radiotherapy in selected patients with high-risk melanoma. Multimodality therapy has not been well studied and is not standardized. Adjuvant radiotherapy seems to improve locoregional control but does not improve overall survival. Elective neck dissection is advocated in patients with oral PMMs. Systemic therapy should be considered only for patients with metastatic or unresectable locoregional disease. Despite improvements in the field of surgery, radiotherapy and systemic therapy, patients with PMMs still face a very unfavorable prognosis (5-year disease free survival less than 20%) with high rates of recurrence and metastasis. The present review aims to summarize the current state knowledge on the molecular biology, pathological diagnosis and management of this disease.
Keywords		kemoterapija rak glave in vratu radioterapija diagnostika chemotherapy head and neck cancer radiotherapy diagnosis