Author/Editor		Samuels, Stuart E.; Strojan, Primož
Title		Management of locally advanced HPV-related oropharyngeal squamous cell carcinoma
Type		članek
Publication year		2015
Volume		str. [1-11]
ISSN		0937-4477 - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Language		eng
Abstract		HPV-related (HPV+) oropharyngeal cancer (OPC) has a better prognosis compared to HPV unrelated (HPV%) OPC. This review summarizes and discusses several of the controversies regarding the management of HPV+ OPC, including the mechanism of its treatment sensitivity, modern surgical techniques, chemotherapy regimens, and treatment de-intensification protocols. We also discuss and reconsider potential adverse prognostic factors such as tumor EGFR expression, tumor hypoxia, and patient smoking history, as well as the significance of retropharyngeal adenopathy. Finally, we discuss elective nodal treatment of uninvolved lymph node stations. While this review does not exhaust all controversies related to the management of HPV+ OPC, it aims to highlight some of the most clinically relevant ones.
Keywords		humani papilomski virus orofaringealen karcinom orofaringealen rak hipoksija radioterapija HPV oropharyngeal carcinoma hypoxia radiotherapy