Author/Editor		Jenko, Barbara; Praprotnik, Sonja; Čučnik, Saša; Rotar, Žiga; Tomšič, Matija; Dolžan, Vita
Title		Survivin polymorphism is associated with disease activity in rheumatoid arthritis patients
Type		članek
Vol. and No.		Letnik 17, št. 1
Publication year		2016
Volume		str. 37-45
ISSN		1462-2416 - Pharmacogenomics
Language		eng
Abstract		Aim: Survivin expression was associated with unfavorable and erosive course of rheumatoid arthritis (RA). This is the first study investigating association between BIRC5 polymorphisms, survivin plasma levels and disease activity in RA. Patients & Methods: A testing group of 123 and validation group of 150 RA patients initially treated with methotrexate monotherapy were genotyped for three BIRC5 promoter polymorphisms. Survivin plasma levels were determined in testing group. Results: BIRC5 c.-31G>C was marginally associated with treatment response after 6 months of methotrexate treatment (p = 0.046) and with DAS28 at the time of inclusion in testing (p = 0.052) and in validation group (p = 0.057). Survivin plasma levels were not associated with BIRC5 polymorphisms or DAS28. Conclusion: BIRC5 -31C>G polymorphism could be useful pharmacogenetic marker for methotrexate treatment response in RA.
Keywords		genetic polymorphism methotrexate rheumatoid arthritis genski polimorfizem metotreksat revmatoidni artritis