Author/Editor		Thorn, Peter; Zorec, Robert; Rettig, Jens; Keating, Damien J
Title		Exocytosis in non-neuronal cells
Type		članek
Publication year		2016
ISSN		0022-3042 - Journal of neurochemistry
Language		eng
Abstract		Exocytosis is the process by which stored neurotransmitters and hormones are released via the fusion of secretory vesicles with the plasma membrane. It is a dynamic, rapid and spatially restricted process involving multiple steps including vesicle trafficking, tethering, docking, priming and fusion. For many years great steps have been undertaken in our understanding of how exocytosis occurs in different cell types, with significant focus being placed on synaptic release and neurotransmission. However this process of exocytosis is an essential component of cell signalling throughout the body and underpins a diverse array of essential physiological pathways. Many similarities exist between different cell types with regard to key aspects of the exocytosis pathway, such as the need for Ca2+ to trigger it or the involvement of members of the SNARE protein families. However it is also equally clear that non-neuronal cells have acquired highly specialised mechanisms to control the release of their own unique chemical messengers. This review will focus on several important non-neuronal cell types and discuss what we know about the mechanisms they use to control exocytosis and how their specialised output is relevant to the physiological role of each individual cell type. These include enteroendocrine cells, pancreatic [beta]-cells, astrocytes, lactotrophs and cytotoxic T lymphocytes.
Keywords		endokrine celice citotoksični limfociti T eksocitoze endocrine cells cytotoxic T lymphocytes exocytosis