Author/Editor | Kirchheiner, Kathrin; Šegedin, Barbara | |
Title | Dose-effect relationship and risk factors for vaginal stenosis after definitive radio(chemo)therapy with image-guided brachytherapy for locally advanced cervical cancer in the EMBRACE study | |
Type | članek | |
Vol. and No. | Letnik 118, št. 1 | |
Publication year | 2016 | |
Volume | str. 160-166 | |
ISSN | 0167-8140 - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology | |
Language | eng | |
Abstract | To identify risk factors for vaginal stenosis and to establish a dose-effect relationship for image-guided brachytherapy in locally advanced cervical cancer. MATERIALS/METHODS: Patients from the ongoing EMBRACE study with prospectively assessed morbidity (CTCAEv3.0) at baseline and at least one follow-up were selected. Patient-, disease- and treatment characteristics were tested as risk factors for vaginal stenosis G>2 in univariate and multivariable analyses (Cox proportional hazards model) and a dose-effect curve was deduced from the estimates. The ICRU rectum point was used to derive the recto-vaginal reference point dose. | |
Keywords | radioterapija brahiterapija rak materničnega vratu radiotherapy brachytherapy cervical cancer |