Author/Editor     Kirchheiner, Kathrin; Šegedin, Barbara
Title     Dose-effect relationship and risk factors for vaginal stenosis after definitive radio(chemo)therapy with image-guided brachytherapy for locally advanced cervical cancer in the EMBRACE study
Type     članek
Vol. and No.     Letnik 118, št. 1
Publication year     2016
Volume     str. 160-166
ISSN     0167-8140 - Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
Language     eng
Abstract     To identify risk factors for vaginal stenosis and to establish a dose-effect relationship for image-guided brachytherapy in locally advanced cervical cancer. MATERIALS/METHODS: Patients from the ongoing EMBRACE study with prospectively assessed morbidity (CTCAEv3.0) at baseline and at least one follow-up were selected. Patient-, disease- and treatment characteristics were tested as risk factors for vaginal stenosis G>2 in univariate and multivariable analyses (Cox proportional hazards model) and a dose-effect curve was deduced from the estimates. The ICRU rectum point was used to derive the recto-vaginal reference point dose.
Keywords     radioterapija
brahiterapija
rak materničnega vratu
radiotherapy
brachytherapy
cervical cancer