Author/Editor		Enache, Daniela; Solomon, Alina; Cavallin, Lena; Kåreholt, Ingemar; Gregorič Kramberger, Milica; Aarsland, Dag; Kivipelto, Miia; Eriksdotter Jönhagen, Maria; Winblad, Bengt; Jelic, Vesna
Title		CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia
Type		članek
Vol. and No.		, št. Vol. 123
Publication year		2016
Volume		str. 124-131
ISSN		0197-4580 - Neurobiology of aging
Language		eng
Abstract		The aim of this study was to explore cross-sectional associations between CAIDE Dementia Risk Score and dementia-related CSF and neuroimaging biomarkers in 724 memory clinic patients without dementia from the Memory Clinic at Karolinska University Hospital Huddinge, Sweden. We additionally evaluated the score%s capacity to predict dementia. Two risk score versions were calculated: one including age, gender, obesity, hyperlipidaemia, and hypertension; and one additionally including APOE %4 carrier status. CSF was analysed for amyloid % (A%), total tau (t-tau), and phosphorylated tau (p-tau). Visual assessments of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal subscale (GCA-F) and Fazekas scale for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly associated with higher t-tau, more severe MTA, WMC and GCA-F. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced A%, more severe MTA and WMC. CAIDE Dementia Risk Score version with APOE seemed to predict dementia better in this memory clinic population with short follow-up than the version without APOE
Keywords		mild cognitive impairment subjective cognitive impairment CAIDE dementia risk score