Author/Editor		Kavalar, Rajko; Fokter, Samo K.; Lamovec, Janez
Title		Total hip arthroplasty-related osteogenic osteosarcoma
Type		članek
Vol. and No.		, št. Vol. 21
Publication year		2016
Volume		str. 1-6
ISSN		0949-2321 - European journal of medical research
Language		eng
Abstract		Background. Orthopedic implant-related sarcoma is an exceedingly rare, but a known complication of total hip arthroplasty (THA). Case presentation. The authors describe clinical and radiologic features, histologic appearance, and treatment of osteogenic osteosarcoma located in the proximal femoral diaphysis associated with an unstable femoral prosthesis following THA in a 65-year-old male patient. The patient with HLA-B27 positive ankylosing spondylitis underwent arthroplasty 15 years ago. Conclusions. The neoplastic process may be considered as an extraordinary complication of THA and might just be coincidental or the result of some derangement of the healing process in host tissue with no definitely proven hypothesis that the implants or their by-products are carcinogenic. The soluble chemical substances from the implanted prosthetic material are, at least in animals, suspected to play a vital role in the pathogenesis of the neoplastic transformation of the bone tissue. The presented case shall alert orthopedic surgeons to clinical, radiologic, and macroscopic similarities between a malignant tumor and benign lesions caused by wear debris at THA sites. At the examination of plane X-rays of patients with THA loosening, the differential diagnosis should always include osteogenic sarcoma, as well. To our knowledge, there have been only nine cases of THA-related osteogenic osteosarcomas described in the English-language literature.
Keywords		kolk artroplastika vsadki in proteze osteosarkom rak (medicina) ortopedija