Author/Editor		Lim, Dmitry; Rodríguez Arellano, José Julio; Parpura, Vladimir; Zorec, Robert; Zeidán-Chuliá, Fares; Genazzani, Armando A.; Verkhratsky, Alexei
Title		Calcium signalling toolkits in astrocytes and spatio-temporal progression of Alzheimer's diseases
Type		članek
Vol. and No.		Letnik 13, št. 4
Publication year		2016
Volume		str. 359-369
ISSN		1567-2050 - Current Alzheimer research
Language		eng
Abstract		Pathological remodelling of astroglia represents an important component of the pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and reactivity; which may be specific for different stages of the disease evolution. Astroglial reactivity represents the generic defensive mechanism, and inhibition of astrogliotic response exacerbates b-amyloid pathology associated with AD. In animal models of AD astroglial reactivity is different in different brain regions, and the deficits of reactive response observed in entorhinal and prefrontal cortices may be linked to their vulnerability to AD progression. Reactive astrogliosis is linked to astroglial Ca2+ signalling, this latter being widely regarded as a mechanism of astroglial excitability. The AD pathology evolving in animal models as well as acute or chronic exposure to [beta]-amyloid induce pathological remodelling of Ca2+ signalling toolkit in astrocytes. This remodelling modifies astroglial Ca2+ signalling and may be linked to cellular mechanisms of AD pathogenesis.
Keywords		Alzheimer's disease astrocyte neuroglia Alzheimerjeva bolezen astrocit nevroglija