Author/Editor		Cerar Kišek, Tjaša; Strle, Franc; Stupica, Daša; Ružić-Sabljić, Eva; McHugh, Gail; Steere, Allen C.; Strle, Klemen
Title		Differences in genotype, clinical features, and inflammatory potential of Borrelia burgdorferi sensu stricto strains from Europe and the United States
Type		članek
Vol. and No.		Letnik 22, št. 5
Publication year		2016
Volume		str. 818-827
ISSN		1080-6040 - Emerging infectious diseases
Language		eng
Abstract		Borrelia burgdorferi sensu stricto isolates from patients with erythema migrans in Europe and the United States were compared by genotype, clinical features of infection, and inflammatory potential. Analysis of outer surface protein C and multilocus sequence typing showed that strains from these 2 regions represent distinct genotypes. Clinical features of infection with B. burgdorferi in Slovenia were similar to infection with B. afzelii or B. garinii the other 2 Borrelia spp. that cause disease in Europe, whereas B. burgdorferi strains from the United States were associated with more severe disease. Moreover, B. burgdorferi strains from the United States induced peripheral blood mononuclear cells to secrete higher levels of cytokines and chemokines associated with innate and Th1-adaptive immune responses, whereas strains from Europe induced greater Th17-associated responses. Thus, strains of the same B. burgdorferi species from Europe and the United States represent distinct clonal lineages that vary in virulence and inflammatory potential.
Keywords		Borrelia burgdorferi genotip vnetni potencial Evropa Borrelia burgdorferi genotype Inflammatory potential