Author/Editor | Hellquist, Henrik; Skálová, Alena; Barnes, Leon; Cardesa, Antonio; Thompson, Lester D. R.; Triantafyllou, Asterios; Williams, Michelle D.; Devaney, Kenneth O.; Gnepp, Douglas R.; Bishop, Justin A.; Strojan, Primož | |
Title | Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma | |
Type | članek | |
Vol. and No. | Letnik 33, št. 3 | |
Publication year | 2016 | |
Volume | str. 357-368 | |
ISSN | 0741-238X - Advances in therapy | |
Language | eng | |
Abstract | Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation. | |
Keywords | rak glave in vratu adenoidni cistični karcinom žleze slinavke limfne metastaze head and neck cancer adenoid cystic carcinoma lymphatic metastasis salivary glands |