Author/Editor     Hellquist, Henrik; Skálová, Alena; Barnes, Leon; Cardesa, Antonio; Thompson, Lester D. R.; Triantafyllou, Asterios; Williams, Michelle D.; Devaney, Kenneth O.; Gnepp, Douglas R.; Bishop, Justin A.; Strojan, Primož
Title     Cervical lymph node metastasis in high-grade transformation of head and neck adenoid cystic carcinoma
Type     članek
Vol. and No.     Letnik 33, št. 3
Publication year     2016
Volume     str. 357-368
ISSN     0741-238X - Advances in therapy
Language     eng
Abstract     Adenoid cystic carcinoma (AdCC) is among the most common malignant tumors of the salivary glands. It is characterized by a prolonged clinical course, with frequent local recurrences, late onset of metastases and fatal outcome. High-grade transformation (HGT) is an uncommon phenomenon among salivary carcinomas and is associated with increased tumor aggressiveness. In AdCC with high-grade transformation (AdCC-HGT), the clinical course deviates from the natural history of AdCC. It tends to be accelerated, with a high propensity for lymph node metastasis. In order to shed light on this rare event and, in particular, on treatment implications, we undertook this review: searching for all published cases of AdCC-HGT. We conclude that it is mandatory to perform elective neck dissection in patients with AdCC-HGT, due to the high risk of lymph node metastases associated with transformation.
Keywords     rak glave in vratu
adenoidni cistični karcinom
žleze slinavke
limfne metastaze
head and neck cancer
adenoid cystic carcinoma
lymphatic metastasis
salivary glands