Author/Editor		Kwon, Jeanny; Kim, Byoung Hyuck; Jung, Hee-Won; Bešić, Nikola; Sugitani, Iwao; Wu, Hong-Gyun
Title		The prognostic impacts of postoperative radiotherapy in the patients with resected anaplastic thyroid carcinoma
Type		članek
Vol. and No.		, št. Vol. 59
Publication year		2016
Volume		str. 34-45
ISSN		0959-8049 - European journal of cancer (Oxford, England : 1990)
Language		eng
Abstract		Optimal postoperative managements for anaplastic thyroid carcinoma (ATC) have not yet been sufficiently clarified. We conducted a systematic review and meta-analysis focussing on the impact of postoperative radiotherapy (PORT) in the patients with resected ATC. Materials and methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines, a comprehensive search was performed in the several databases. We included the studies that reported survival outcome in the patients with or without PORT following any type of surgical resection except biopsy only. Hazard ratio (HR) was extracted, and the random-effects model was used for the pooled analysis. Results: Seventeen retrospective studies including 1147 analysable patients met all inclusion criteria. The overall research quality was relatively low with considerable methodological limitations. The pooled results showed that PORT significantly reduced the risk of death in all the patients with resected ATC compared with those with surgery alone (HR, 0.556; 95% confidence interval, 0.419e0.737; p < 0.001). Exploratory analyses demonstrated that patients with stage IVA (HR, 0.364; p Z 0.012) and IVB (HR, 0.460; p Z 0.059) may also have survival benefit from PORT, whereas stage IVC may not. No evidence of publication bias was found (p Z 0.352). Conclusions: This study is the first meta-analysis assessing PORT in patients with ATC and provides convincing evidence that adequate resection followed by PORT may offer the prolonged survival. However, without evidence based on prospective randomised trials, it is still not known which subset of patients can really benefit from PORT.
Keywords		anaplastični rak ščitnice radioterapija pooperativna radioterapija rak ščitnice anaplastic thyroid carcinoma postoperative radiotherapy radiotherapy thyroid carcinoma