Author/Editor		Rades, Dirk; Conde-Moreno, Antonio J.; Cacicedo, Jon; Šegedin, Barbara; Veninga, Theo; Schild, Steven E.
Title		Metastatic spinal cord compression
Type		članek
Vol. and No.		Letnik 35, št. 11
Publication year		2015
Volume		str. 6189-6192
ISSN		0250-7005 - Anticancer research
Language		eng
Abstract		Metastatic spinal cord compression (MSCC) is an oncological emergency. Many elderly patients cannot tolerate intensive treatment and need individual approaches accounting for a patient's remaining lifetime. The goal of the present study was to develop a survival score for elderly prostate cancer patients with MSCC. PATIENTS AND METHODS: Nine characteristics were analyzed in 243 patients: age, performance status, interval from prostate cancer diagnosis until MSCC, affected vertebrae, ambulatory status, further bone lesions, visceral metastases, time developing motor deficits, fractionation schedule. RESULTS: Pre-radiotherapy ambulatory status (p<0.001), visceral metastases (p<0.001) and time developing motor deficits (p<0.001) were significant for survival on Cox regression analysis and included in the survival score. Four groups were defined: 9-12, 13-16, 17-19 and 21-23 points. Six-month survival rates were 7%, 28%, 71% and 95%, respectively (p<0.001). CONCLUSION: The present study identified four groups with different survival probabilities that require treatment strategies with different priorities ranging from symptom control to prolongation of life.
Keywords		rak prostate iradiacija starejši bolniki radioterapija preživetje celokupno preživetje prostate cancer elderly patients radiotherapy overall survival irradiation