Author/Editor		Ihan, A; Križman, I; Ferlan-Marolt, V; Tepež, B; Gubina, M
Title		HLA-DR expression on CD8 lymphocytes from gastric mucosa in urease-positive and urease-negative gastritis
Type		članek
Source		FEMS Immunol Med Microbiol
Vol. and No.		Letnik 10, št. 3-4
Publication year		1995
Volume		str. 295-9
Language		eng
Abstract		We isolated lymphocytes from chronically inflamed gastric mucosa. We analysed the expression of IL-2 receptors (CD25), transferin receptors (CD71) and HLA-DR molecules on T lymphocytes by flow cytometric analysis in 16 patients with urease-positive and in 7 patients with urease-negative chronic gastritis. In G0, G1 and G2 histological type (Sydney classification) of gastritis the number of lymphocytes obtained from the gastric mucosa biopsies was too low for the flow cytometric analysis. However, in G3 histological type of chronic gastritis we obtained enough cells for the flow cytometric analysis in 75 percent. We demonstrated a significant increase in HLA-DR expression on CD8 cells from patients with urease-positive gastritis compared to urease-negative gastritis. We also observed a statistically non-significant increase in HLA-DR expression on CD3 cells, and in CD71 expression on both CD3 and CD8 cells in urease-positive gastritis. However, no difference in CD25 expression was found between the two types of gastritis.
Descriptors		CD8-POSITIVE T-LYMPHOCYTES GASTRITIS HLA-DR ANTIGENS UREASE ANTIGENS, CD3 CHRONIC DISEASE FLOW CYTOMETRY GASTRIC MUCOSA HELICOBACTER PYLORI HELICOBACTER INFECTIONS LYMPHOCYTE COUNT RECEPTORS, INTERLEUKIN-2 RECEPTORS, TRANSFERRIN