Author/Editor		Seidl, Daniel; Janssen, Stefan; Strojan, Primož; Hakim, Samer G.; Wollenberg, Barbara; Schild, Steven E.; Rades, Dirk
Title		Importance of chemotherapy and radiation dose after microscopically incomplete resection of stage III/IV head and neck cancer
Type		članek
Vol. and No.		Letnik 36, št. 5
Publication year		2016
Volume		str. 2487-2491
ISSN		0250-7005 - Anticancer research
Language		eng
Abstract		To investigate the importance of chemotherapy and radiation dose after R1 resection of squamous cell carcinoma of the head-and-neck (SCCHN). Patients and Methods: One hundred and twenty-two patients receiving radiotherapy alone or with concurrent chemotherapy [cisplatin or cisplatin/5-fluorouracil (5-FU)] were retrospectively analyzed. Results: On multivariate analysis, chemotherapy was significantly associated with improved locoregional control (p=0.048). Three-year locoregional control rates were 61% for those treated without chemotherapy, 83% for those treated with cisplatin and 77% for those treated with cisplatin/5-FU. Radiation doses of 66 and 70 Gy were non-significantly superior to 60-64 Gy (p=0.18). On multivariate analysis, chemotherapy showed a trend for improving survival (p=0.055). Three-year OS rates were 51% for those without chemotherapy, 65% for those treated with cisplatin and 57% for those treated with cisplatin/5-FU. Radiation doses of 66 Gy (3-year survival=61%) and 70 Gy (70%) were superior to 60-64 Gy (25%) (p=0.021). Conclusion: Concurrent chemotherapy and a radiation dose of 66 Gy resulted in better outcomes. Cisplatin and cisplatin/5-FU were similarly effective. Radiation doses >66 Gy appear not to be necessary.
Keywords		rak glave in vratu radioterapija ploščatocelični rak paliativno obsevanje head and neck cancer radiotherapy squamous cell carcinoma palliative radiation therapy