Author/Editor		Seidl, Daniel; Janssen, Stefan; Strojan, Primož; Bajrovic, Amira; Schild, Steven E.; Rades, Dirk
Title		Prognostic factors after definitive radio(chemo)therapy of locally advanced head and neck cancer
Type		članek
Vol. and No.		Letnik 36, št. 5
Publication year		2016
Volume		str. 2523-2526
ISSN		0250-7005 - Anticancer research
Language		eng
Abstract		To identify predictors of locoregional control (LRC) and overall survival (OS) after definitive radio(chemo)therapy for squamous cell carcinoma of the head and neck (SCCHN). PATIENTS AND METHODS: Two hundred and seventy-five patients were evaluated; 261 patients received radiochemotherapy with 30-40 mg/m(2) of cisplatin weekly, three courses of cisplatin 100 mg/m(2), two courses of cisplatin 5x20 mg/m(2) or two courses of cisplatin 5%20 mg/m(2)plus 5-fluorouracil. Ten characteristics were analyzed: Pre-radiotherapy hemoglobin, T-/N-category, Karnofsky performance-score (KPS), gender, age, chemotherapy type, tumor site, grading and radiation dose. RESULTS: On multivariate analyses, hemoglobin 12-14 g/dl (p=0.040), lower T-category (p=0.010), lower N-category (p=0.042) and female gender (p=0.006) were predictive of LRC. Hemoglobin >12 g/dl (p=0.020), lower N-category (p<0.001), KPS %80 (p<0.001), female gender (p=0.024) and cisplatin 100 mg/m(2) or 5%20 mg/m(2) (p<0.001) were predictors of improved OS. CONCLUSION: Predictors of LRC and OS were identified that can improve personalization of treatment. Since chemotherapy type was associated with OS, studies comparing different regimens are warranted.
Keywords		rak glave in vratu radioterapija ploščatocelični rak preživetje head and neck cancer radiotherapy squamous cell carcinoma overall survival