Author/Editor     Terzič, Tea; Kastelic, Matej; Dolžan, Vita; Kores-Plesničar, Blanka
Title     Genetic polymorphisms in dopaminergic system and treatment-resistant schizophrenia
Type     članek
Vol. and No.     Letnik 28, št. 2
Publication year     2016
Volume     str. 127-131
ISSN     0353-5053 - Psychiatria Danubina
Language     eng
Abstract     Background: Dopaminergic system plays an important role in ant ipsychotic response. Func tional single nucleotide polymorphisms (SNPs) can change dopamine receptor expression or dopamine disposition and thus influence response to anti- psychotic treatment. Subjects and methods: 138 schizophrenia patients were stratified in the treatment-resistant and tr eatment-responsive group. Control group consisted of 94 healthy blood donors. All subjects we re genotyped for the following SNPs: DRD1 (rs4532, rs5326), DRD2 (rs1801028, rs1799732), DRD3 (rs6280) and COMT (rs165815, rs4680). Association between the genotypes and clinical symptoms were tested using ANCOVA with cu rrent antipsychotic dose as a confounder. Di fferences in allele frequencies between treatment-responsive and treatment-resistant schizophrenic patients were assessed using % 2 tests. Results: No statistically significant associations were observed between any of the inves tigated genotypes and c linical scores and occurrence of the treatment- resistant schizophrenia. Conclusions: Genetic variability in dopaminergic syst em does not have a major role in clinical symptoms and occurrence of treatment-resistant schizophren ia among Slovenian patients.
Keywords     dopamine
single nucleotide polymorphism
schizophrenia
dopamin
polimorfizem posameznih nukleotidov
shizofrenija