Author/Editor | Rigoutsos, Isidore; Lee, Sang Kil; Nam, Su Youn; Catela Ivkovic, Tina; Pichler, Martin; Rossi, Simona; Clark, Peter; Yi, Jing; Ling, Hui; Ferdin, Jana | |
Title | N-BLR, a primate-specific non-coding transcript, modulates the epithelial-to-mesenchymal transition and leads to colorectal cancer invasion and migration | |
Type | članek | |
Source | In: bioRxiv beta : the preprint server for biology Cold Spring Harbor, N.Y. : Cold Spring Harbor Laboratory | |
Publication year | 2014 | |
Volume | str. 1-27 | |
Language | eng | |
Abstract | Non-coding RNAs have been commanding increasingly greater attention in recent years as the few that have been functionalized to date play important roles in key cellular processes. Here we show that N-BLR, a ~900 bp non-coding RNA, modulates the epithelial-to-mesenchymal transition, increase s colorectal cancer invasion, and functions as a migration enabler by affecting the expression of ZEB1 and E-cadherin. In patients with colorectal cancer, N-BLR expression associates with tumor stage and invasion potential. As N-BLR contains several instances of a category of DNA motifs known as pyknons, we also designed a custom-made array to investigate the possibility that other pyknon loci may be transcribed. For several of the loci probed by the array we found that the corresponding pyknons are differentially expressed between cancer and normal tissue samples. Taken together the data suggest that a systematic study of other pyknon- containing non-coding RNAs like N-BLR may be warranted in the context of colorectal cancer. | |
Keywords | rak debelega črevesa in danke nekodiran RNA prepis colorectal cancer non-coding RNA transcription |