| Author/Editor | Homšak, Evgenija; Ekart, Robert | |
| Title | Hemodiafiltration affects NT-proBNP but not ST2 serum concentration in end-stage renal disease patients | |
| Type | članek | |
| Vol. and No. | Letnik 49, št. 15 | |
| Publication year | 2016 | |
| Volume | str. 1159-1163 | |
| ISSN | 0009-9120 - Clinical biochemistry | |
| Language | eng | |
| Abstract | Background: Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) is already established, and soluble ST2 (sST2) is a new promising marker, for evaluating and monitoring patients undergoing hemodiafiltration (HDF) who are at increased risk for cardiovascular events. Although HDF is known to affect the concentration of some biochemical parameters, the exact effect on the concentration of sST2 has not yet been studied. The aim of this study was to assess the effect of HDF on serum sST2 and NT-proBNP concentrations in End-stage Renal Disease (ESRD) patients. Methods: sST2 and NT-proBNP were measured in serum samples from 55 patients with ESRD before and after HDF (F5008 Dialysis machines, Fresenius Medical Care, Milsons Point, NSW, Australia), using an ELISA method for sST2 (Presage ST2 Assay, Critical Diagnostics, San Diego, CA, USA) and a one-step sandwich chemiluminescent immunoassay based on LOCI technology for NT-proBNP (Dimension Vista System 1500, Siemens Healthcare Diagnostics Inc., Newark, NJ, USA), respectively. Results: The median (interquartile range) NT-proBNP concentration decreased from 728 (332-2832) to 256 (140-813) pmol/L after HDF (P < 0.001). The mean individual decrease was - 62.8 +/- 12.9% with a minimum of - 29.1% and maximum of - 97.6%. The concentration of sST2 median (interquartile range) remained unchanged after HDF: 28.0 (24.0-33.1) ng/mL before HDF and 28.0 (22.0-33.1) ng/mL after HDF; P = 0.579). Conclusions: There is a significant decrease of NT-proBNP after HDF, whereas sST2 remains unaffected by HDF. Care should be taken when interpreting NT-proBNP results having regard to the time since the last dialysis. sST2 measurement can be done at any time, relative to HDF. | |
| Keywords | hemodiafiltracija N-končni natriuretični propeptid tipa B končna ledvična bolezen srčno-žilne bolezni prognoza SST2 |