Author/Editor		Hudler, Petra
Title		Aberrant patterns of DNA methylation in cancer
Type		članek
Source		In: Encyclopedia of life sciences [Chichester] : Wiley InterScience
Publication year		2016
Volume		str. 1-10
Language		eng
Abstract		Deoxyribonucleic acid (DNA) methylation is an epigenetic mechanism involved in the regulation of gene expression and preservation of genome stability in normal cells. Alterations of DNA methylation code have been associated with the development and progression of many diseases, including cancer. Novel technologies allow genome-wide interrogation of methylation patterns. Data on different types of cancer are accumulating; however, elucidation of the consequences of all observed demethylation or methylation events and understanding their associations with other genomic aberrations present great challenges for the future research. Nevertheless, several findings regarding gene silencing by hypermethylation of CpG islands in promoters of genes have been successfully transferred in clinical setting aiding in diagnosis or prognosis of different types of cancer. In addition, therapeutic application of small molecule inhibitors of DNA methyltransferases (DNMTs) to reverse epigenetic silencing has been proven to be beneficial for treatment of various cancers.
Keywords		metilacija DNA neobičajni vzorci rak DNA methylation aberrant patterns cancer