Author/Editor     Tozon, Nataša; Lampreht Tratar, Urša; Žnidar, Katarina; Serša, Gregor; Teissie, Justin; Čemažar, Maja
Title     Operating procedures of the electrochemotherapy for treatment of tumor in dogs and cats
Type     članek
Vol. and No.     , št. 116
Publication year     2016
ISSN     1940-087X - Journal of visualized experiments : JoVE
Language     eng
Abstract     Electrochemotherapy (ECT) is a local approach which is used for treating solid tumors of different histologies. Its mechanism is based on cell membrane permeabilization by means of electroporation. To achieve the electroporation of the cells, electric pulses are generated by a generator and delivered to the target tissue by the use of electrodes. Electroporation is a physical method which is used to introduce molecules, like cytostatic drugs, into the cells that could not pass the cell membrane on their own. In electrochemotherapy, currently, cisplatin and bleomycin are clinically used. Electrochemotherapy antitumor effectiveness is high, for example up to 100% complete response of canine mast cell tumors smaller than 2 cm3 was achieved. Additionally, electrochemotherapy can be used for the treatment of inoperable tumors. One of the important characteristics of electrochemotherapy is that it can be effective as a one-time treatment only. However, in the case of failure or partial tumor response it can be repeated several times with equal or improved effectiveness. Electrochemotherapy is already a standard treatment for cutaneous and subcutaneous tumors of various histologies in human and veterinary oncology. Furthermore, several clinical studies exploiting electrochemotherapy for deep-seated tumors are on-going.
Keywords     elektrokemoterapija
elektroporacija
veterinarska onkologija
psi
mastocitom
electrochemotherapy
electroporation
veterinary oncology
dogs
mast cell tumor