| Author/Editor | Lenarčič, B; Krašovec, M; Ritonja, A; Olafsson, I; Turk, V | |
| Title | Inactivation of human cystatin C and kininogen by human cathepsin D | |
| Type | članek | |
| Source | FEBS Lett | |
| Vol. and No. | Letnik 280, št. 2 | |
| Publication year | 1991 | |
| Volume | str. 211-5 | |
| Language | eng | |
| Abstract | A papain inhibitor of 22 kDa was isolated from human placenta and shown to be identical to residues Cys246-Leu373 of the third domain of human kininogen. This kininogen domain and recombinant human cystatin C were inactivated by peptide bond cleavages at hydrophobic amino acid residues due to the action of cathepsin D. These results further support the proposed role of cathepsin D in the regulation of cysteine proteinase activity. | |
| Descriptors | CATHEPSIN D CYSTATINS KININOGENS AMINO ACID SEQUENCE CHROMATOGRAPHY, HIGH PRESSURE LIQUID CYSTEINE PROTEINASES ENZYME ACTIVATION KININOGENS MOLECULAR SEQUENCE DATA PLACENTA PROTEIN DENATURATION RECOMBINANT PROTEINS |