| Author/Editor | Boltežar, Lučka; Žagar, Ivana; Jezeršek Novaković, Barbara | |
| Title | Granulomatosis after autologous stem cell transplantation in nonHodgkin lymphoma | |
| Type | članek | |
| Vol. and No. | Letnik 50, št. 4 | |
| Publication year | 2016 | |
| Volume | str. 355-359, I | |
| ISSN | 1318-2099 - Radiology and oncology | |
| Language | eng | |
| Abstract | Sarcoidosis before and after treatment of malignancy is an important differential diagnosis that has to be distinguished from lymphoma. Patients and methods. Hodgkin lymphoma, diffuse large B-cell lymphoma and aggressive follicular lymphoma are being staged and treatment effect is evaluated with PET-CT. We report three cases of aggressive lymphoma after high dose therapy and autologous stem cell transplantation with positive lymph nodes on PET-CT, which were histologically diagnosed as sarcoidosis/granulomatosis. In the literature, we found that false positive lymph nodes were more common after allogeneic than after autologous transplantation. Conclusions. Post-treatment PET-CT positive lymph nodes should always be examined histologically prior to any further treatment decision to avoid unnecessary toxic procedures.Sarkoidoza pred in po zdravljenju raka je pomembna diferencialna diagnoza, ki jo je potrebno razlikovati od limfoma. Bolniki in metode. Za oceno razširjenosti bolezni in učinkovitosti zdravljenja v skladu z novimi priporočili pri Hodgkinovem limfomu, difuznem velikoceličnem B limfomu in agresivnem folikularnem limfomu uporabljamo PET-CT. V članku opisujemo tri primere suma na ponovitev agresivnega limfoma (metabolno aktivne bezgavke na PET-CT) po visokodoznem zdravljenju in avtologni presaditvi krvotvornih matičnih celic. Pri vseh treh bolnikih smo histološko diagnosticirali sarkoidozo/ granulomatozo. V literaturi smo zasledili, da so lažno pozitivne bezgavke pogostejše po alogenični kot pa po avtologni presaditvi matičnih celic. Zaključki. Na PET-CT ugotovljene metabolno aktivne bezgavke po zdravljenju limfoma je potrebno vedno histološko opredeliti pred kakršno koli odločitvijo o nadaljnjem zdravljenju. Tako se izognemo morebitnim nepotrebnim postopkom, ki imajo lahko hude neželene učinke. | |
| Keywords | granulomatoza neHodginov limfom diferencialna diagnoza granulomatosis nonHodgin lymphoma PET-CT differential diagnosis |