Author/Editor		Muhaxheri, G; Vučićević-Boras, Vanja; Gabric, D; Terlević Dabić, Diana; Jurisic Kvesic, A
Title		No efficacy of photodynamic therapy with toluidine blue in oral lichen planus
Type		članek
Vol. and No.		Letnik 8, št. 1
Publication year		2017
Volume		str. 132-134
ISSN		0975-8585 - Research journal of pharmaceutical, biological and chemical sciences
Language		eng
Abstract		Oral lichen planus (OLP) is one of the commonest oral mucosal diseases. It is thought to be autoimmune disease mediated through T - lymphocytes to a still unknown antigen. Gold standard are topical corticosteroids although in some cases they are not useful. Furthermore, certain side - effects with prolonged use have been reported. Lately the role of photodynamic therapy has emerged as one of the treatment modalities, however, results from the studies are scarce. Therefore, we evaluated use of toluidine blue with GaAlAs laser (685 nm wavelength, 2.00 J/cm 2 , power 30mW, area 1.00 cm 2 , time 01ms, frequency continuous ) in five patients with resistant oral lichen planus (unresponsive to topical c orticosteroid treatment) every two days (total number of six irradiations). The results of this study showed that this therapy was not efficient in patients with OLP. Therefore, we do not suggest use of toluidine - mediated photodynamic therapy in some patie nts with refractory oral lichen planus.
Keywords		bolezni sluznice fotodinamičma terapija zdravljenje mucosal disease photodynamic therapy treatment