| Author/Editor | Echanique, Kristen A.; Desai, Stuti V.; Marchiano, Emily; Spinazzi, Eleonora F.; Strojan, Primož; Baredes, Soly; Anderson Eloy, Jean | |
| Title | Laryngeal verrucous carcinoma | |
| Type | članek | |
| Vol. and No. | Letnik 156, št. 1 | |
| Publication year | 2017 | |
| Volume | str. 38-45 | |
| ISSN | 1097-6817 - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery | |
| Language | eng | |
| Abstract | Laryngeal verrucous carcinoma (LVC) is a rare, locally invasive neoplasm comprising 1% to 3.4% of laryngeal carcinomas. Management strategies are a topic of ongoing conversation, and no definitive treatment protocol based on T stage and presentation exists. This review examines characteristics, treatment modalities, and patient outcomes of LVC. DATA SOURCES: PubMed, MEDLINE, EMBASE, and Web of Science. METHODS: Databases were searched through October 29, 2015, for literature detailing individual patient cases of LVC. Variables analyzed included patient demographics, tumor characteristics, tumor size, treatment, and outcomes. RESULTS: Thirty-seven articles with 369 cases were included. LVC was found more commonly in males (13.8:1), at an average age of 58.7 years, and located in the glottis (74.0%). Most patients had local disease at presentation (94.9%). The most common presenting symptom was hoarseness (92.3%). The most common primary treatment was surgery alone (72.3%), with local excision as the most common technique (56.8%). In patients with data available on both surgical modality and T stage, most patients who presented as T1 and were managed surgically underwent local excision (79.2%). Surgical treatment alone led to high rates of disease-free survival at follow-up (86.8%). A large number of patients presenting with T1 disease were disease free at follow-up (88.6%). Overall survival was 80.3%. CONCLUSION: LVC is most often managed surgically. The extent of surgical resection may be guided by T stage, with smaller tumors resected via local excision and larger tumors via partial or total laryngectomy. Regardless of T stage or therapy, LVC has a good posttreatment prognosis. | |
| Keywords | Ackermanov tumor rak grla laringealni rak laringealni karcinom laryngeal cancer Ackerman¼s tumor laryngeal carcinom |