Author/Editor     Cary, Daniele C.; Peterlin, Matija Boris
Title     Targeting the latent reservoir to achieve functional HIV cure
Type     članek
Vol. and No.     , št. Vol. 5
Publication year     2016
Volume     str. 1-8
Language     eng
Abstract     While highly active anti-retroviral therapy has greatly improved the lives of HIV-infected individuals, current treatments are unable to completely eradicate the virus. This is due to the presence of HIV latently infected cells which harbor transcriptionally silent HIV. Latent HIV does not replicate or produce viral proteins, thereby preventing efficient targeting by anti-retroviral drugs. Strategies to target the HIV latent reservoir include viral reactivation, enhancing host defense mechanisms, keeping latent HIV silent, and using gene therapy techniques to knock out or reactivate latent HIV. While research into each of these areas has yielded promising results, currently no one mechanism eradicates latent HIV. Instead, combinations of these approaches should be considered for a potential HIV functional cure.
Keywords     virus HIV
anti-retroviral therapy
functional cure
virus HIV
protivirusno zdravljenje
funkcionalno zdravljenje