Author/Editor		Fakin, B
Title		Factors contributing to the chronic venous insufficiency
Type		članek
Source		Acta Dermatovenerol Alp Pannon Adriat
Vol. and No.		Letnik 4, št. 2
Publication year		1995
Volume		str. 51-4
Language		eng
Abstract		Isufficiency - whether retrograde or anterograde - of the venous circulation in the lower extremities causes hemodynamic disturbances. This appear first in the large veins and thence spread to the venous capillaries. A high venous pressure that fails to decline or declines inadequately with muscular activity leads to anatomical and functional changes in the microcirculation: inflammation, edema, a low pO2, stimulation of fibroblasts and collagen formation. Fibrinolytic activity is reduced, and elevated fibrinogen levels in blood result in the formation of fibrin cuffs. The concomitant involvemet of the lymphatic system contributes to the development of lymphedema. All these changes are ultimately manifested in the clinical picture of chronic venous, or venous and lymphatic, insufficiency.
Descriptors		VENOUS INSUFFICIENCY VARICOSE VEINS VARICOSE ULCER