Author/Editor		Bolha, Luka; Ravnik-Glavač, Metka; Glavač, Damjan
Title		Long noncoding RNAs as biomarkers in cancer
Type		članek
Vol. and No.		, št. Vol. 2017
Publication year		2017
Volume		str. 1-14
ISSN		0278-0240 - Disease markers
Language		eng
Abstract		Long noncoding RNAs (lncRNAs) are a relatively well-characterized class of noncoding RNA (ncRNA) molecules, involved in the regulation of various cell processes, including transcription, intracellular trafficking, and chromosome remodeling. Their deregulation has been associated with the development and progression of various cancer types, the fact which makes them suitable as biomarkers for cancer diagnosis and prognosis. In recent years, detection of cancer-associated lncRNAs in body fluids of cancer patients has proven itself as an especially valuable method to effectively diagnose cancer. Cancer diagnosis and prognosis employing circulating lncRNAs are preferential when compared to classical biopsies of tumor tissues, especially due to their noninvasiveness, and have great potential for routine usage in clinical practice. Thus, this review focuses on summarizing the perspectives of lncRNAs as biomarkers in cancer, based on evaluating their expression profiles determined in body fluids of cancer patients.
Keywords		long noncoding RNAs biomarkers cancer dolge nekodirajoče RNA označevalci rak